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Portal Colatina em Ação – 17/06/2020
Em testes de laboratório, material inativou em dois minutos 99,9% da quantidade de SARS-CoV-2; tecnologia desenvolvida por startup apoiada pelo PIPE-FAPESP será usada na produção de máscaras de proteção e roupas hospitalares (imagem: Nanox/divulgação ) Elton Alisson | Agência FAPESP – Pesquisadores da empresa paulista Nanox, apoiada pelo Programa FAPESP Pesquisa Inovativa em Pequenas Empresas (PIPE); desenvolveram um tecido com micropartículas de prata na superfície que demonstrou ser capaz de inativar o coronavírus SARS-CoV-2.
Em testes de laboratório, o material foi capaz de eliminar 99,9% da quantidade do vírus após dois minutos de contato.
O desenvolvimento do material teve a colaboração de pesquisadores do Instituto de Ciências Biomédicas da Universidade de São Paulo (ICB-USP), da Universitat Jaume I, da Espanha; e do Centro de Desenvolvimento de Materiais Funcionais (CDMF) Centros de Pesquisa, Inovação e Difusão (CEPIDs) apoiados pela FAPESP.
“Já entramos com o pedido de depósito de patente da tecnologia e temos parcerias com duas tecelagens no Brasil que irão utilizá-la para a fabricação de máscaras de proteção e roupas hospitalares”; conforme diz à Agência FAPESP Luiz Gustavo Pagotto Simões
Leia também …. Vacina contra coronavírus “não será cara”, promete Universidade de Oxford
Indústrias têxteis 3i4r2c O tecido é composto por uma mistura de poliéster e de algodão (polycotton) e contém dois tipos de micropartículas de prata impregnadas na superfície por meio de um processo de imersão; seguido então de secagem e fixação, chamado pad-dry-cure.
A Nanox já fornecia para indústrias têxteis e de diversos outros segmentos essas micropartículas; que apresentam atividade antibacteriana e fungicida, e em tecidos evitam a proliferação de fungos e bactérias causadoras de maus odores (leia mais em agencia.fapesp.br/30037/
Com o surgimento do novo coronavírus e a chegada da pandemia no Brasil; os pesquisadores da empresa tiveram a ideia de avaliar se esses materiais também eram capazes de inativar o SARS-CoV-2; uma vez que já havia sido demonstrado em trabalhos científicos a ação contra alguns tipos de vírus.
Crescidos em células 5d2e5r Para realizar os ensaios, a empresa se associou ena pesquisadores do ICB-USP, que conseguiram logo no início da epidemia então o Brasil isolar e cultivar em laboratório o SARS-CoV-2 obtido dos dois primeiros pacientes brasileiros diagnosticados com a doença no Hospital Israelita Albert Einstein (leia mais em agencia.fapesp.br/32692/
Leia também …. Vacina contra coronavírus “não será cara”, promete Universidade de Oxford 144k1h Amostras de tecido com e sem micropartículas de prata incorporadas na superfície foram caracterizadas por pesquisadores da Universitat Jaume I e do CDMF por espectroscopia e colocadas em tubos contendo uma solução com grandes quantidades de SARS-CoV-2, crescidos em células.
As amostras foram mantidas em contato direto com os vírus em intervalos de tempo diferentes, de dois e cinco minutos, para avaliar afinal a atividade antiviral.
Os experimentos foram feitos duas vezes, em dois dias diferentes e por dois grupos diferentes de pesquisadores; de modo que a análise dos resultados fosse feita então de forma cega.
Presente nas células 5c4v1v Os resultados das análises por quantificação do material genético viral por PCR indicaram que as amostras de tecido com diferentes micropartículas de prata incorporadas na superfície inativaram 99,9%; das cópias do novo coronavírus presentes nas células após dois e cinco minutos de contato.
Leia também ….. Reino Unido fara testes de uma vacina experimental contra o novo coronavírus
“A quantidade de vírus que colocamos nos tubos em contato com o tecido é muito superior à que uma máscara de proteção é exposta e, mesmo assim; o material foi capaz de eliminar o vírus com essa eficácia”; conforme diz Lucio Freitas Junior
“É como se uma máscara de proteção feita com o tecido recebesse um balde de partículas contendo o vírus e ficasse encharcada”, comparou o pesquisador.
Além de testes para avaliação da atividade antiviral, antimicrobiana e fungicida, o material também ou por ensaios para avaliação do potencial alérgico; fotoirritante e fotossensível, para eliminar assim o risco de causar problemas dermatológicos.
Aplicação em outros materiais 4a2x1p A empresa pretende avaliar agora a duração do efeito antiviral das micropartículas no tecido. Em testes relacionados à propriedade bactericida, os materiais foram capazes de controlar fungos e bactérias em tecidos mesmo após 30 lavagens, afirma Simões.
“Como o material apresenta essa propriedade bactericida mesmo após 30 lavagens, provavelmente mantém a atividade antiviral por esse mesmo tempo”, conforme estima.
Primeiro resultado 6d3q De acordo com o pesquisador, as micropartículas podem ser aplicadas em qualquer tecido composto por uma mistura de fibras naturais e sintéticas. Além de tecidos, a empresa afinal está testando agora a capacidade de inativação do novo coronavírus pelas micropartículas de prata incorporadas à superfície de outros materiais; como filmes plásticos e um polímero flexível; semelhante a uma borracha, que utilizou para desenvolver uma máscara de proteção contra o novo coronavírus em parceria com a fabricante de brinquedos Elka (leia mais em agencia.fapesp.br/32982
“O tecido foi o primeiro resultado da aplicação das micropartículas de prata para inativar o novo coronavírus. Mas, em breve, devemos ter vários outros”, afirma Simões.
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